BIOME is an experimental biodesign project that explores the possibility of living products by integrating living organisms as functional design components. Centered on Physarum polycephalum (slime mould), the project combines scientific experimentation with design methodologies to develop proofs of concept that demonstrate adaptive, responsive, and aesthetic potentials of living matter. Beyond object-making, BIOME prototypes material systems, interfaces, and care practices that allow living materials to remain stable and safe outside conventional laboratory settings. A key focus is the decentralization of biodesign knowledge—supporting community engagement and enabling the growth of living matter beyond labs through open protocols, documentation, and locally adaptable recipes. By coupling hands-on practice with education, the project invites cross-disciplinary participation while foregrounding ethics, care, and risk stewardship. BIOME envisions a resilient and regenerative future shaped through symbiotic, more-than-human design practices.