As global cities pursue sustainability, Indigenous communities in Ladakh, once deeply attuned to their high-altitude cold desert bioregions, are increasingly drawn toward extractive capitalist-driven development that threatens fragile ecosystems. This shift began five decades ago with the region’s exposure to tourism and modernisation. This project explores how creative cultural-ecological strategies rooted in Indigenous wisdom can reconcile modern aspirations with ecological limits. Framed as design research, the project functions as a toolkit, guide, and case study proposing place-based, community-led regenerative pathways for Ladakh’s transitioning villages and other eco-sensitive regions in India and the Global South. Key outcomes include a Theory of Change vision, a Community-Led Assessment, Action and Planning toolkit, and experimental village models envisioned as Regenerative Living Hubs with integrated value chains and waste-to-energy systems. Together, these strategies encourage collective regenerative thinking, stewardship of bioregional resources, and more conscious, responsible ways of living and designing within nature’s interconnected web.